ARG56156
anti-Spred 1 antibody
anti-Spred 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Spred 1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Specificity | This Spred1 antibody is predicted to have no cross-reactivity to Spred2 or Spred3. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Spred 1 |
| Immunogen | Synthetic peptide (14 aa) within aa. 250-300 of Human Spred1. |
| Conjugation | Un-conjugated |
| Alternate Names | PPP1R147; NFLS; spred-1; hSpred1; Spred-1; Sprouty-related, EVH1 domain-containing protein 1 |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Human brain tissue lysate |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q7Z699 Human Sprouty-related, EVH1 domain-containing protein 1 Swiss-port # Q924S8 Mouse Sprouty-related, EVH1 domain-containing protein 1 |
|---|---|
| Gene Symbol | SPRED1 |
| Gene Full Name | sprouty-related, EVH1 domain containing 1 |
| Background | The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008] |
| Function | Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity). [UniProt] |
| Calculated MW | 50 kDa |
| PTM | Phosphorylated on tyrosine. |
