ARG52425
anti-Stargazin antibody
anti-Stargazin antibody for Western blot and Rat
Signaling Transduction antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Stargazin |
|---|---|
| Tested Reactivity | Rat |
| Predict Reactivity | Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Stargazin |
| Antigen Species | Mouse |
| Immunogen | Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH |
| Conjugation | Un-conjugated |
| Alternate Names | Voltage-dependent calcium channel gamma-2 subunit; TARP gamma-2; Neuronal voltage-gated calcium channel gamma-2 subunit; MRD10; Transmembrane AMPAR regulatory protein gamma-2 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | Specific for the ~36k stargazin protein. Immunolabeling of the stargazin band is blocked by preadsorption with the peptide used as antigen. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity Purified |
| Buffer | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| Stabilizer | 0.1 mg/ml BSA, 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | CACNG2 |
|---|---|
| Gene Full Name | calcium channel, voltage-dependent, gamma subunit 2 |
| Background | Stargazin is a member of the transmembrane AMPAR regulatory proteins (TARP) family and is involved in glutamate receptor trafficking. It has been recently demonstrated (Tomita et al., 2005; Priel et al., 2005) that the interaction between stargazin and AMPA receptors is critical for the correct localization of the receptors at the synapse. Phosphorylation of the stargazin protein at Thr 321 by Protein Kinase A regulates its interaction with PSD-95 and synaptic targeting of AMPA receptors (Choi et al., 2002). |
| Research Area | Signaling Transduction antibody |
| Calculated MW | 36 kDa |
| PTM | Phosphorylation of Thr-321 impairs interaction with DLG1 and DLG4. |
