ARG63381

anti-Syntrophin antibody

anti-Syntrophin antibody for Western blot and Human,Mouse,Rat

Signaling Transduction antibody

Overview

Product Description Goat Polyclonal antibody recognizes Syntrophin
Tested Reactivity Hu, Ms, Rat
Predict Reactivity Cow, Dog, Pig
Tested Application WB
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name Syntrophin
Antigen Species Human
Immunogen ASGRRAPRTGLLE-C
Conjugation Un-conjugated
Alternate Names dJ1187J4.5; Syntrophin-1; SNT1; LQT12; 59 kDa dystrophin-associated protein A1 acidic component 1; Pro-TGF-alpha cytoplasmic domain-interacting protein 1; Alpha-1-syntrophin; TACIP1

Application Instructions

Application Suggestion
Tested Application Dilution
WB1 - 3 µg/ml
Application Note WB: Recommend incubate at RT for 1h.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 6640 Human SNTA1

Swiss-port # Q13424 Human Alpha-1-syntrophin

Background Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jul 2012]
Research Area Signaling Transduction antibody
Calculated MW 54 kDa
PTM Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity).