ARG63181
anti-TBL1X / TBL1XR1 antibody
anti-TBL1X / TBL1XR1 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Cancer antibody; Gene Regulation antibody; Metabolism antibody; Neuroscience antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes TBL1X / TBL1XR1 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms, Rat, Cow, Dog |
| Tested Application | IHC-P |
| Specificity | This antibody is also expected to recognise the human protein TBLR1 (NP_078941), which is very similar. Variants (NP_005638.1; NP_001132938.1) encode isoform a (TBL1X) and variants (NP_001132939.1; NP_001132940.1 ) encode isoform b (TBLX1). |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TBL1X / TBL1XR1 |
| Antigen Species | Human |
| Immunogen | SASDGSVCVLDLRK |
| Conjugation | Un-conjugated |
| Alternate Names | Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linked; EBI; SMAP55; TBL1; F-box-like/WD repeat-containing protein TBL1X |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | IHC-P: Antigen Retrieval: Steam tissue section in Tris/EDTA buffer (pH 9.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by antigen affinity chromatography. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O60907 Human F-box-like/WD repeat-containing protein TBL1X |
|---|---|
| Gene Symbol | TBL1X |
| Gene Full Name | transducin (beta)-like 1X-linked |
| Background | The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq, Nov 2008] |
| Function | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. [UniProt] |
| Research Area | Cancer antibody; Gene Regulation antibody; Metabolism antibody; Neuroscience antibody |
| Calculated MW | 62 kDa |
