ARG55115
anti-TBX21 / T-bet antibody
anti-TBX21 / T-bet antibody for ELISA,ICC/IF,Western blot and Human,Mouse
Developmental Biology antibody; Gene Regulation antibody; Immune System antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TBX21 / T-bet |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | ELISA, ICC/IF, WB |
| Specificity | TBX21 antibody is human and mouse reactive. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TBX21 / T-bet |
| Antigen Species | Human |
| Immunogen | Synthetic peptide (19 aa) within the last 50 aa of Human TBX21 / T-bet protein. |
| Conjugation | Un-conjugated |
| Alternate Names | T-box protein 21; T-box transcription factor TBX21; TBET; T-cell-specific T-box transcription factor T-bet; T-bet; T-PET; TBLYM; Transcription factor TBLYM |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | Cat. No. 1210- 293 Cell Lysate |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | TBX21 |
| Gene Full Name | T-box 21 |
| Background | TBX21 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Members of this family include transcription factors involved in the regulation of developmental processes. Studies in mouse and humans show that TBX21 is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma. Expression of the human ortholog also correlates with interferon-gamma expression in Th1 and natural killer cells, suggesting a TBX21 may play a role in initiating Th1 lineage development from naive Th precursor cells. |
| Function | Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. [UniProt] |
| Research Area | Developmental Biology antibody; Gene Regulation antibody; Immune System antibody |
| Calculated MW | 58 kDa |
