ARG53688
anti-TGF beta 3 antibody
anti-TGF beta 3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Cancer antibody; Developmental Biology antibody; Signaling Transduction antibody
Publication1
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TGF beta 3 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, IP, WB |
| Specificity | The antibody majorly reacts to TGF beta 3, but also reacts to TGF beta 2 with weak signals. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TGF beta 3 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide derived from C-terminus of the precursor form of human TGF beta 3 (CYLRSADTTHSTVLGLYNTLNPEASAS). |
| Conjugation | Un-conjugated |
| Alternate Names | TGF-beta3; RNHF; LAP; ARVD; ARVD1; Transforming growth factor beta-3; TGF-beta-3 |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-P: Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Incubation Time: 10 min at RT. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| Positive Control | Placenta |
Properties
| Form | Liquid |
|---|---|
| Purification | Immunogen affinity purified |
| Buffer | PBS (pH 7.6), 1% BSA and < 0.1% Sodium azide |
| Preservative | < 0.1% Sodium azide |
| Stabilizer | 1% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | TGFB3 |
| Gene Full Name | transforming growth factor, beta 3 |
| Background | This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009] |
| Function | Involved in embryogenesis and cell differentiation. [UniProt] |
| Cellular Localization | Cytoplasm |
| Research Area | Cancer antibody; Developmental Biology antibody; Signaling Transduction antibody |
| Calculated MW | 12.5 kDa (reduced); 25 kDa (non-reduced) |
| PTM | The precursor is cleaved into mature TGF-beta-3 and LAP, which remains non-covalently linked to mature TGF-beta-3 rendering it inactive. |
Specific References
Pathobiological Study of Leiomyomatoid Angiomatous Neuroendocrine Tumor (LANT)-Like Tumor in the Myometrium.
IHC-P / Human
