ARG41933

anti-TGM2 / Tissue transglutaminase antibody

anti-TGM2 / Tissue transglutaminase antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation and Human,Mouse

Overview

Product Description Rabbit Polyclonal antibody recognizes TGM2 / Tissue transglutaminase
Tested Reactivity Hu, Ms
Tested Application IHC-P, IP, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name TGM2 / Tissue transglutaminase
Antigen Species Human
Immunogen Synthetic peptide of Human TGM2 / Tissue transglutaminase.
Conjugation Un-conjugated
Alternate Names TG2; G-ALPHA-h; TGase H; Transglutaminase C; TGase C; HEL-S-45; Transglutaminase-2; Tissue transglutaminase; C; TGase-2; TGC; Protein-glutamine gamma-glutamyltransferase 2; TG; Transglutaminase H; GNAH; EC 2.3.2.13

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:50 - 1:200
IP1:50
WB1:1000 - 1:5000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control HUVEC
Observed Size ~ 77 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 21817 Mouse TGM2

GeneID: 7052 Human TGM2

Swiss-port # P21980 Human Protein-glutamine gamma-glutamyltransferase 2

Swiss-port # P21981 Mouse Protein-glutamine gamma-glutamyltransferase 2

Gene Symbol TGM2
Gene Full Name transglutaminase 2
Background Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. [UniProt]
Calculated MW 77 kDa