ARG22416
anti-TGN46 antibody
anti-TGN46 antibody for ICC/IF,IHC-Frozen sections,Western blot and Human,Primates
Overview
| Product Description | Sheep Polyclonal antibody recognizes TGN46 This antibody recognizes Trans-Golgi network integral membrane protein 2 (TGOLN2), also known as TGN38 homolog, TGN46, TGN48 or Trans-Golgi network protein TGN51. TGN46 is a 437 amino acid glycoprotein localized to the Trans-Golgi network. TGN46 has been reported as being the best available marker for human trans-Golgi network.TGN46 is a heavily glycosylated protein of around 110-120 kDa. Multiple isoforms of TGN46 are generated by alternative splicing difffering in sequence at the C-terminal protion. Sheep anti Human TGN46 antibody is expeced to recognize all identified isoforms. |
|---|---|
| Tested Reactivity | Hu, NHuPrm |
| Tested Application | ICC/IF, IHC-Fr, WB |
| Host | Sheep |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TGN46 |
| Antigen Species | Human |
| Immunogen | Recombinant human TGN46. |
| Conjugation | Un-conjugated |
| Alternate Names | Trans-Golgi network protein TGN51; TGN48; TGN46; TGN51; Trans-Golgi network integral membrane protein 2; TGN38 homolog; TTGN2; TGN38 |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-Fr: Fixation with 3% paraformaldehyde or methanol/acetone is recommended. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS, 0.02% Sodium azide, 25% Glycerol and 1% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 25% Glycerol and 1% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O43493 Human Trans-Golgi network integral membrane protein 2 |
|---|---|
| Gene Symbol | TGOLN2 |
| Gene Full Name | trans-golgi network protein 2 |
| Background | This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] |
| Function | May be involved in regulating membrane traffic to and from trans-Golgi network. [UniProt] |
| Calculated MW | 46 kDa (unmodified). 110-120 kDa (glycosylated) |
