ARG40049

anti-THOC7 antibody

anti-THOC7 antibody for Western blot and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes THOC7
Tested Reactivity Hu, Ms, Rat
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name THOC7
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 1-204 of Human THOC7 (NP_079351.2).
Conjugation Un-conjugated
Alternate Names fSAP24; THO complex subunit 7 homolog; NIF3L1-binding protein 1; hTREX30; Functional spliceosome-associated protein 24; Ngg1-interacting factor 3-like protein 1-binding protein 1; NIF3L1BP1

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Rat brain, Mouse kidney and Jurkat
Observed Size 24 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 66231 Mouse THOC7

GeneID: 80145 Human THOC7

Swiss-port # Q6I9Y2 Human THO complex subunit 7 homolog

Swiss-port # Q7TMY4 Mouse THO complex subunit 7 homolog

Gene Symbol THOC7
Gene Full Name THO complex 7
Function Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. [UniProt]
Cellular Localization Cytoplasm. Nucleus. Nucleus speckle. Note=Interaction with THOC5 is required for nuclear localization. [UniProt]
Calculated MW 24 kDa