ARG59115
anti-TIAM1 antibody
anti-TIAM1 antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TIAM1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TIAM1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to aa. 1518-1554 of Human TIAM1. (ASVDRDLQERLQATSISQRERGRKTLDSHASRMAQLK) |
| Conjugation | Un-conjugated |
| Alternate Names | TIAM-1; T-lymphoma invasion and metastasis-inducing protein 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q13009 Human T-lymphoma invasion and metastasis-inducing protein 1 |
|---|---|
| Gene Symbol | TIAM1 |
| Gene Full Name | T-cell lymphoma invasion and metastasis 1 |
| Function | Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration. [UniProt] |
| Cellular Localization | Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. [UniProt] |
| Calculated MW | 178 kDa |
