ARG59766

anti-TICAM1 / TRIF antibody

anti-TICAM1 / TRIF antibody for Western blot and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes TICAM1 / TRIF
Tested Reactivity Hu, Ms, Rat
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name TICAM1 / TRIF
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 20-200 of Human TICAM1 (NP_891549.1).
Conjugation Un-conjugated
Alternate Names Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adapter molecule 1; Proline-rich, vinculin and TIR domain-containing protein B; TICAM-1; TRIF; MyD88-3; PRVTIRB; IIAE6; Putative NF-kappa-B-activating protein 502H

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Rat spleen, Mouse spleen and U-251MG
Observed Size ~ 76 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 106759 Mouse TICAM1

GeneID: 148022 Human TICAM1

Swiss-port # Q80UF7 Mouse TIR domain-containing adapter molecule 1

Swiss-port # Q8IUC6 Human TIR domain-containing adapter molecule 1

Gene Symbol TICAM1
Gene Full Name toll-like receptor adaptor molecule 1
Background This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]
Function Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. [UniProt]
Cellular Localization Cytoplasmic vesicle, autophagosome. Note=Colocalizes with UBQLN1 in the autophagosome. [UniProt]
Calculated MW 76 kDa
PTM Phosphorylated by TBK1.

Polyubiquitinated by TRIM38 with 'Lys-48'-linked chains, leading to proteasomal degradation. [UniProt]