ARG66922
anti-TIM3 antibody [SQab22265]
anti-TIM3 antibody [SQab22265] for IHC-Formalin-fixed paraffin-embedded sections and Human
Immune System antibody
Overview
Product Description | Recombinant Rabbit Monoclonal antibody [SQab22265] recognizes TIM3 |
---|---|
Tested Reactivity | Hu |
Tested Application | IHC-P |
Host | Rabbit |
Clonality | Monoclonal |
Clone | SQab22265 |
Isotype | IgG |
Target Name | TIM3 |
Antigen Species | Human |
Immunogen | A synthetic peptide corresponding to the sequence of Human TIM-3. |
Conjugation | Un-conjugated |
Protein Full Name | Hepatitis A virus cellular receptor 2 |
Alternate Names | KIM-3; TIM3; TIMD-3; Tim-3; TIM-3; CD366; T-cell immunoglobulin and mucin domain-containing protein 3; TIMD3; T-cell membrane protein 3; HAVcr-2; T-cell immunoglobulin mucin receptor 3; Hepatitis A virus cellular receptor 2 |
Application Instructions
Application Suggestion |
|
||||
---|---|---|---|---|---|
Application Note | IHC-P: Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer (pH 9.0). Incubate the samples at RT (18-25°C) for 44 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
||||
Positive Control | Human tonsil |
Properties
Form | Liquid |
---|---|
Purification | Purification with Protein A. |
Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA. |
Preservative | 0.01% Sodium azide |
Stabilizer | 40% Glycerol and 0.05%BSA |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links |
Swiss-port # Q8TDQ0 Human Hepatitis A virus cellular receptor 2 |
---|---|
Gene Symbol | HAVCR2 |
Gene Full Name | hepatitis A virus cellular receptor 2 |
Background | The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011] |
Function | Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. [UniProt] |
Highlight | Related products: Anti-Rabbit IgG secondary antibodies; Related news: New PD-1 ELISA Kit, excellent for preclinical studies or pharmatheutical development |
Research Area | Immune System antibody |
Calculated MW | 33 kDa |
PTM | O-glycosylated with core 1 or possibly core 8 glycans. Phosphorylated on tyrosine residues; modestly increased after TCR/CD28 stimulation. Can be phosphorylated in the cytoplasmatic domain by FYN (By similarity). Phosphorylation at Tyr-265 is increased by stimulation with ligand LGALS9. |