ARG58694

anti-TLS / FUS antibody

anti-TLS / FUS antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes TLS / FUS
Tested Reactivity Hu, Ms, Rat
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name TLS / FUS
Antigen Species Human
Immunogen Synthetic peptide derived from Human TLS / FUS.
Conjugation Un-conjugated
Alternate Names TLS; Translocated in liposarcoma protein; ETM4; POMp75; FUS1; ALS6; RNA-binding protein FUS; Oncogene TLS; POMP75; 75 kDa DNA-pairing protein; Oncogene FUS; HNRNPP2

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:50 - 1:200
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 233908 Mouse FUS

GeneID: 2521 Human FUS

Swiss-port # P35637 Human RNA-binding protein FUS

Swiss-port # P56959 Mouse RNA-binding protein FUS

Gene Symbol FUS
Gene Full Name FUS RNA binding protein
Background This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
Function Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity. [UniProt]
Cellular Localization Nucleus. [UniProt]
Calculated MW 53 kDa
PTM Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine. [UniProt]