ARG58722
anti-TLS / FUS antibody
anti-TLS / FUS antibody for Western blot and Human
Overview
Product Description | Rabbit Polyclonal antibody recognizes TLS / FUS |
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Tested Reactivity | Hu |
Tested Application | WB |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | TLS / FUS |
Antigen Species | Human |
Immunogen | Recombinant fusion protein corresponding to aa. 297-526 of Human FUS (NP_004951.1). |
Conjugation | Un-conjugated |
Alternate Names | TLS; Translocated in liposarcoma protein; ETM4; POMp75; FUS1; ALS6; RNA-binding protein FUS; Oncogene TLS; POMP75; 75 kDa DNA-pairing protein; Oncogene FUS; HNRNPP2 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
Positive Control | U937 | ||||
Observed Size | 70 kDa |
Properties
Form | Liquid |
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Purification | Affinity purified. |
Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
Preservative | 0.02% Sodium azide |
Stabilizer | 50% Glycerol |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | FUS |
Gene Full Name | FUS RNA binding protein |
Background | This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009] |
Function | Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity. [UniProt] |
Cellular Localization | Nucleus. [UniProt] |
Calculated MW | 53 kDa |
PTM | Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine. [UniProt] |