ARG56190
anti-TOX3 antibody [TOX3/1124]
anti-TOX3 antibody [TOX3/1124] for Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody [TOX3/1124] recognizes TOX3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | TOX3/1124 |
| Isotype | IgG1, kappa |
| Target Name | TOX3 |
| Antigen Species | Human |
| Immunogen | A recombinant fragment (139 amino acid residues around aa 200-400) from the human TOX3 protein. |
| Conjugation | Un-conjugated |
| Alternate Names | Trinucleotide repeat-containing gene 9 protein; TNRC9; TOX high mobility group box family member 3; CAG trinucleotide repeat-containing gene F9 protein; CAGF9 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 0.1 mg/ml BSA |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O15405 Human TOX high mobility group box family member 3 |
|---|---|
| Gene Symbol | TOX3 |
| Gene Full Name | TOX high mobility group box family member 3 |
| Background | The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009] |
| Function | Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. [UniProt] |
| Cellular Localization | Cytoplasmic & nuclear |
| Calculated MW | 63 kDa |
