ARG64974

anti-TPP1 antibody

anti-TPP1 antibody for Western blot and Human

Cell Biology and Cellular Response antibody; Neuroscience antibody

Overview

Product Description Goat Polyclonal antibody recognizes TPP1
Tested Reactivity Hu
Predict Reactivity Cow, Dog
Tested Application WB
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name TPP1
Antigen Species Human
Immunogen C-TPSVIRKRYNLTSQD
Conjugation Un-conjugated
Alternate Names EC 3.4.14.9; TPP-1; Tripeptidyl-peptidase I; GIG1; Lysosomal pepstatin-insensitive protease; SCAR7; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase 1; CLN2; LPIC; Cell growth-inhibiting gene 1 protein; TPP-I

Application Instructions

Application Suggestion
Tested Application Dilution
WB0.3 - 1 µg/ml
Application Note WB: Recommend incubate at RT for 1h.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 1200 Human TPP1

Swiss-port # O14773 Human Tripeptidyl-peptidase 1

Background This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]
Research Area Cell Biology and Cellular Response antibody; Neuroscience antibody
Calculated MW 61 kDa
PTM Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity.