ARG40250
anti-TRAF7 antibody
anti-TRAF7 antibody for Western blot and Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TRAF7 |
|---|---|
| Tested Reactivity | Ms |
| Predict Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TRAF7 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Human TRAF7. |
| Conjugation | Un-conjugated |
| Alternate Names | E3 ubiquitin-protein ligase TRAF7; RING finger and WD repeat-containing protein 1; EC 6.3.2.-; RFWD1; RING finger protein 119; TNF receptor-associated factor 7; RNF119 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Mouse fetal stomach | ||||
| Observed Size | 65 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | TRAF7 |
|---|---|
| Gene Full Name | TNF receptor-associated factor 7, E3 ubiquitin protein ligase |
| Background | Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004] |
| Function | E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. [UniProt] |
| Cellular Localization | Cytoplasmic vesicle. [UniProt] |
| Calculated MW | 75 kDa |
| PTM | Phosphorylated by MAP3K3. Ubiquitinates itself upon phosphorylation. [UniProt] |
