ARG20578
anti-TRAP1 antibody [Trap1-6] (Biotin)
anti-TRAP1 antibody [Trap1-6] (Biotin) for ICC/IF and Human
Overview
| Product Description | Biotin-conjugated Mouse Monoclonal antibody [Trap1-6] recognizes TRAP1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | Trap1-6 |
| Isotype | IgG2a, kappa |
| Target Name | TRAP1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human TRAP1. |
| Conjugation | Biotin |
| Alternate Names | HSP90L; Tumor necrosis factor type 1 receptor-associated protein; TRAP-1; TNFR-associated protein 1; Heat shock protein 75 kDa, mitochondrial; HSP 75; HSP75 |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.09% azide and 50% Glycerol. |
| Preservative | 0.09% azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Keep the antibody in the dark and keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q12931 Human Heat shock protein 75 kDa, mitochondrial |
|---|---|
| Gene Symbol | TRAP1 |
| Gene Full Name | TNF receptor-associated protein 1 |
| Background | This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
| Function | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. [UniProt] |
| Calculated MW | 80 kDa |
