ARG23873
anti-TREM2 antibody [78.18]
anti-TREM2 antibody [78.18] for Flow cytometry and Mouse
Overview
| Product Description | Rat Monoclonal antibody [78.18] recognizes TREM2 |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | FACS |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | 78.18 |
| Isotype | IgG1 |
| Target Name | TREM2 |
| Antigen Species | Mouse |
| Immunogen | Mouse TREM-2 Fc fusion protein. |
| Conjugation | Un-conjugated |
| Alternate Names | Trem2a; Trem2b; TREM-2; Triggering receptor expressed on myeloid cells 2; Triggering receptor expressed on monocytes 2; Trem2c |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | FACS: Use 10 µl of the suggested working dilution to label 1x10^6 cells in 100 µl. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS and 0.09% Sodium azide. |
| Preservative | 0.09% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q99NH8 Mouse Triggering receptor expressed on myeloid cells 2 |
|---|---|
| Gene Symbol | TREM2 |
| Gene Full Name | triggering receptor expressed on myeloid cells 2 |
| Background | This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012] |
| Function | May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. [UniProt] |
| Cellular Localization | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted. [UniProt] |
| Calculated MW | 25 kDa |
