ARG23873

anti-TREM2 antibody [78.18]

anti-TREM2 antibody [78.18] for Flow cytometry and Mouse

Overview

Product Description Rat Monoclonal antibody [78.18] recognizes TREM2
Tested Reactivity Ms
Tested Application FACS
Host Rat
Clonality Monoclonal
Clone 78.18
Isotype IgG1
Target Name TREM2
Antigen Species Mouse
Immunogen Mouse TREM-2 Fc fusion protein.
Conjugation Un-conjugated
Alternate Names Trem2a; Trem2b; TREM-2; Triggering receptor expressed on myeloid cells 2; Triggering receptor expressed on monocytes 2; Trem2c

Application Instructions

Application Suggestion
Tested Application Dilution
FACS1:25 - 1:200
Application Note FACS: Use 10 µl of the suggested working dilution to label 1x10^6 cells in 100 µl.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein G.
Buffer PBS and 0.09% Sodium azide.
Preservative 0.09% Sodium azide
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 83433 Mouse TREM2

Swiss-port # Q99NH8 Mouse Triggering receptor expressed on myeloid cells 2

Gene Symbol TREM2
Gene Full Name triggering receptor expressed on myeloid cells 2
Background This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Function May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. [UniProt]
Cellular Localization Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted. [UniProt]
Calculated MW 25 kDa