ARG54895

anti-TREM2 antibody

anti-TREM2 antibody for Western blot and Human

Immune System antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes TREM2
Tested Reactivity Hu
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name TREM2
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide corresponding to aa. 22-50 (N-terminus) of Human TREM2.
Conjugation Un-conjugated
Alternate Names Trem2a; Trem2b; TREM-2; Triggering receptor expressed on myeloid cells 2; Triggering receptor expressed on monocytes 2; Trem2c

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control MDA-MB-435

Properties

Form Liquid
Purification Purification with Protein A and immunogen peptide.
Buffer PBS and 0.09% (W/V) Sodium azide
Preservative 0.09% (W/V) Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 54209 Human TREM2

Swiss-port # Q9NZC2 Human Triggering receptor expressed on myeloid cells 2

Gene Symbol TREM2
Gene Full Name triggering receptor expressed on myeloid cells 2
Background This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Function May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. [UniProt]
Cellular Localization Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted.
Research Area Immune System antibody
Calculated MW 25 kDa