ARG63496
anti-TRIM37 antibody
anti-TRIM37 antibody for Flow cytometry,ICC/IF and Human
Overview
| Product Description | Goat Polyclonal antibody recognizes TRIM37 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Cow, Dog |
| Tested Application | FACS, ICC/IF |
| Specificity | Reported variants represent identical protein (NP_056109.1; NP_001005207.1). |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TRIM37 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around the C-terminus of Human TRIM37. (C-EDLSFNTDENSGR) (NP_056109.1) |
| Conjugation | Un-conjugated |
| Alternate Names | TRIM37; tripartite motif-containing 37; MUL; TEF3; KIAA0898; MUL protein; RING-B-box-coiled-coil protein; POB1; tripartite motif-containing 37 protein |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O94972 Human E3 ubiquitin-protein ligase TRIM37 |
|---|---|
| Gene Symbol | TRIM37 |
| Gene Full Name | tripartite motif containing 37 |
| Background | This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. [provided by RefSeq, Mar 2016] |
| Function | E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724). [UniProt] |
| Cellular Localization | Cytoplasm, perinuclear region. Peroxisome. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. [UniProt] |
| Calculated MW | 108 kDa |
| PTM | Auto-ubiquitinated. [UniProt] |
