ARG41394
anti-TRP1 antibody
anti-TRP1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TRP1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TRP1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide derived from Human TRP1. |
| Conjugation | Un-conjugated |
| Alternate Names | CATB; TYRP; b-PROTEIN; EC 1.14.18.-; CAS2; DHICA oxidase; Melanoma antigen gp75; 5,6-dihydroxyindole-2-carboxylic acid oxidase; Catalase B; OCA3; TRP; GP75; TRP1; Glycoprotein 75; TRP-1; Tyrosinase-related protein 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | ~ 75 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P17643 Human 5,6-dihydroxyindole-2-carboxylic acid oxidase |
|---|---|
| Gene Symbol | TYRP1 |
| Gene Full Name | tyrosinase-related protein 1 |
| Background | This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009] |
| Function | Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. [UniProt] |
| Cellular Localization | Melanosome membrane; Single-pass type I membrane protein. Melanosome. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. [UniProt] |
| Calculated MW | 61 kDa |
| PTM | Glycosylated. [UniProt] |
