ARG22234
anti-TRPC5 antibody [S67-15]
anti-TRPC5 antibody [S67-15] for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Mouse Monoclonal antibody [S67-15] recognizes TRPC5 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, IP, WB |
| Specificity | Detects ~110kDa. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | S67-15 |
| Isotype | IgG2b |
| Target Name | TRPC5 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around aa. 827-845 of Human TrpC5 |
| Conjugation | Un-conjugated |
| Alternate Names | hTRP-5; hTRP5; PPP1R159; Transient receptor protein 5; TrpC5; TRP-5; Short transient receptor potential channel 5; TRP5 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9QX29 Mouse Short transient receptor potential channel 5 Swiss-port # Q9UL62 Human Short transient receptor potential channel 5 |
|---|---|
| Gene Symbol | TRPC5 |
| Gene Full Name | transient receptor potential cation channel, subfamily C, member 5 |
| Background | This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010] |
| Function | Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. [UniProt] |
| Cellular Localization | Membrane |
| Calculated MW | 111 kDa |
