ARG22280
anti-TRPM7 / LTRPC7 antibody [S74-25]
anti-TRPM7 / LTRPC7 antibody [S74-25] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Mouse Monoclonal antibody [S74-25] recognizes TRPM7 / LTRPC7 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Specificity | Detects ~220kDa. No cross-reactivity against TrpM6. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | S74-25 |
| Isotype | IgG1 |
| Target Name | TRPM7 / LTRPC7 |
| Antigen Species | Mouse |
| Immunogen | Fusion protein around aa. 1817-1863 (C- terminus) of Mouse TrpM7 |
| Conjugation | Un-conjugated |
| Alternate Names | Transient receptor potential cation channel subfamily M member 7; CHAK; ALSPDC; LTrpC7; LTRPC7; CHAK1; Channel-kinase 1; TRP-PLIK; EC 2.7.11.1; LTrpC-7; Long transient receptor potential channel 7 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q923J1 Mouse Transient receptor potential cation channel subfamily M member 7 Swiss-port # Q96QT4 Human Transient receptor potential cation channel subfamily M member 7 |
|---|---|
| Gene Symbol | Trpm7 |
| Gene Full Name | transient receptor potential cation channel, subfamily M, member 7 |
| Background | The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| Function | Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). [UniProt] |
| Cellular Localization | Membrane |
| Calculated MW | 213 kDa |
| PTM | Autophosphorylated. |
