ARG22283
anti-TRPV3 antibody [S15-4]
anti-TRPV3 antibody [S15-4] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Mouse Monoclonal antibody [S15-4] recognizes TRPV3 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, IP, WB |
| Specificity | Detects ~70kDa. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | S15-4 |
| Isotype | IgG2a |
| Target Name | TRPV3 |
| Antigen Species | Rat |
| Immunogen | Synthetic peptide around aa. 774-791 (C-terminus) of Rat TrpV3 |
| Conjugation | Un-conjugated |
| Alternate Names | VRL3; VRL-3; TrpV3; Transient receptor potential cation channel subfamily V member 3; OLMS; Vanilloid receptor-like 3; FNEPPK2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8K424 Mouse Transient receptor potential cation channel subfamily V member 3 Swiss-port # Q8NET8 Human Transient receptor potential cation channel subfamily V member 3 |
|---|---|
| Gene Symbol | Trpv3 |
| Gene Full Name | ransient receptor potential cation channel, subfamily V, member 3 |
| Background | This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| Function | Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). [UniProt] |
| Cellular Localization | Membrane |
| Calculated MW | 91 kDa |
