ARG22815
anti-TSHR / TSH Receptor antibody [2C11]
anti-TSHR / TSH Receptor antibody [2C11] for ELISA,Flow cytometry,Immunoprecipitation,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody [2C11] recognizes TSHR / TSH Receptor Mouse anti Human thyroid stimulating hormone receptor antibody, clone 2C11 recognizes the human thyroid stimulating hormone receptor (TSHR) otherwise known as the thyrotropin receptor. TSHR is an important molecule in controlling the growth and function of the normal thyroid.Mouse anti Human thyroid stimulating receptor antibody recognises both native and denatured TSH receptor (binding to an epitope at the carboxy terminus between amino acids 354 and 359). It does inhibit binding of TSH. No cross reactivity has been observed with related LH and FSH receptors.Clone 2C11 recognises the mutant TSH receptor known as I167N as well as the wild type molecule (Costagliola et al. 1998) |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, FACS, IHC-P, IP, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 2C11 |
| Isotype | IgG1 |
| Target Name | TSHR / TSH Receptor |
| Antigen Species | Human |
| Immunogen | Recombinant Human TSH receptor. |
| Conjugation | Un-conjugated |
| Alternate Names | LGR3; TSH-R; CHNG1; Thyrotropin receptor; Thyroid-stimulating hormone receptor; hTSHR-I |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS and 0.09% Sodium azide |
| Preservative | 0.09% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | TSHR |
| Gene Full Name | thyroid stimulating hormone receptor |
| Background | The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] |
| Function | Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5). [UniProt] |
| Calculated MW | 87 kDa |
| PTM | Glycosylated. Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation. |
