ARG64424

anti-TUSC4 / NPRL2 antibody

anti-TUSC4 / NPRL2 antibody for Western blot and Human

Cancer antibody; Gene Regulation antibody

Overview

Product Description Goat Polyclonal antibody recognizes TUSC4 / NPRL2
Tested Reactivity Hu
Predict Reactivity Ms
Tested Application WB
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name TUSC4 / NPRL2
Antigen Species Human
Immunogen QYSNVYCPTPKV
Conjugation Un-conjugated
Alternate Names TUSC4; Gene 21 protein; NPR2; NPR2-like protein; Tumor suppressor candidate 4; Nitrogen permease regulator 2-like protein; G21 protein; NPR2L

Application Instructions

Application Suggestion
Tested Application Dilution
WB0.1 - 0.3 µg/ml
Application Note WB: Recommend incubate at RT for 1h.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 10641 Human NPRL2

Swiss-port # Q8WTW4 Human Nitrogen permease regulator 2-like protein

Gene Symbol NPRL2
Gene Full Name nitrogen permease regulator-like 2 (S. cerevisiae)
Function Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. [UniProt]
Research Area Cancer antibody; Gene Regulation antibody
Calculated MW 44 kDa