ARG42748
anti-TXNDC4 antibody
anti-TXNDC4 antibody for Western blot and Human,Mouse,Rat
Overview
Product Description | Rabbit Polyclonal antibody recognizes TXNDC4 |
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Tested Reactivity | Hu, Ms, Rat |
Tested Application | WB |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | TXNDC4 |
Antigen Species | Human |
Immunogen | Recombinant fusion protein corresponding to aa. 57-406 of Human TXNDC4 (NP_055866.1). |
Conjugation | Un-conjugated |
Alternate Names | Thioredoxin domain-containing protein 4; ERp44; Endoplasmic reticulum resident protein 44; PDIA10; TXNDC4; ER protein 44 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
Positive Control | HepG2 | ||||
Observed Size | ~ 42 kDa |
Properties
Form | Liquid |
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Purification | Affinity purified. |
Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
Preservative | 0.02% Sodium azide |
Stabilizer | 50% Glycerol |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links |
Swiss-port # Q9BS26 Human Endoplasmic reticulum resident protein 44 Swiss-port # Q9D1Q6 Mouse Endoplasmic reticulum resident protein 44 |
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Gene Symbol | ERP44 |
Gene Full Name | endoplasmic reticulum protein 44 |
Background | This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016] |
Function | Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum. [UniProt] |
Cellular Localization | Endoplasmic reticulum lumen. [UniProt] |
Calculated MW | 47 kDa |