ARG42756

anti-TXNDC4 antibody

anti-TXNDC4 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human

Overview

Product Description Rabbit Polyclonal antibody recognizes TXNDC4
Tested Reactivity Hu
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name TXNDC4
Antigen Species Human
Immunogen Fusion protein of Human TXNDC4.
Conjugation Un-conjugated
Alternate Names Thioredoxin domain-containing protein 4; ERp44; Endoplasmic reticulum resident protein 44; PDIA10; TXNDC4; ER protein 44

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:25 - 1:100
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control WB: 231, HeLa, HepG2, A431, K562 and Raji
IHC-P: Human thyroid cancer and Human prostate cancer
Observed Size ~ 47 kDa

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS (pH 7.4), 0.05% Sodium azide and 40% Glycerol.
Preservative 0.05% Sodium azide
Stabilizer 40% Glycerol
Concentration 0.4 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 23071 Human ERP44

Swiss-port # Q9BS26 Human Endoplasmic reticulum resident protein 44

Gene Symbol ERP44
Gene Full Name endoplasmic reticulum protein 44
Background This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016]
Function Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum. [UniProt]
Cellular Localization Endoplasmic reticulum lumen. [UniProt]
Calculated MW 47 kDa