ARG41392

anti-TYROBP / DAP12 antibody

anti-TYROBP / DAP12 antibody for Western blot and Human,Mouse

Overview

Product Description Rabbit Polyclonal antibody recognizes TYROBP / DAP12
Tested Reactivity Hu, Ms
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name TYROBP / DAP12
Antigen Species Human
Immunogen Synthetic peptide around the middle region of Human TYROBP / DAP12. (within the following region: IALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLN)
Conjugation Un-conjugated
Alternate Names TYRO protein tyrosine kinase-binding protein; DNAX-activation protein 12; DAP12; PLOSL; KARAP; KAR-associated protein; Killer-activating receptor-associated protein

Application Instructions

Application Suggestion
Tested Application Dilution
WB1 µg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control HepG2
Observed Size ~ 16 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS, 0.09% (w/v) Sodium azide and 2% Sucrose.
Preservative 0.09% (w/v) Sodium azide
Stabilizer 2% Sucrose
Concentration Batch dependent: 0.5 - 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 22177 Mouse TYROBP

GeneID: 7305 Human TYROBP

Swiss-port # O43914 Human TYRO protein tyrosine kinase-binding protein

Swiss-port # O54885 Mouse TYRO protein tyrosine kinase-binding protein

Gene Symbol TYROBP
Gene Full Name TYRO protein tyrosine kinase binding protein
Background This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
Function Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein. [UniProt]
Calculated MW 12 kDa
PTM Tyrosine phosphorylated. [UniProt]