ARG59797
anti-Telethonin antibody
anti-Telethonin antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Telethonin |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Telethonin |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-167 of Human Telethonin (NP_003664.1). |
| Conjugation | Un-conjugated |
| Alternate Names | telethonin; T-cap; CMH25; Telethonin; CMD1N; TELE; Titin cap protein; LGMD2G |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Rat heart and Mouse skeletal muscle | ||||
| Observed Size | 19 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | TCAP |
| Gene Full Name | titin-cap |
| Background | Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008] |
| Function | Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk. [UniProt] |
| Cellular Localization | Cytoplasm, myofibril, sarcomere. [UniProt] |
| Calculated MW | 19 kDa |
