ARG45084
anti-Themis antibody
anti-Themis antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Themis |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Themis |
| Antigen Species | Human |
| Immunogen | Themis (N-terminal region) antibody was generated from a peptide that included amino acids in the N-terminal region of human themis. This sequence has high homology to the conserved region in rat and mouse themis. |
| Conjugation | Un-conjugated |
| Alternate Names | THEMIS; Thymocyte Selection Associated; C6orf190; C6orf207; THEMIS1; Thymocyte-Expressed Molecule Involved In Selection; Thymocyte Selection Pathway Associated; Protein THEMIS; BA325O24.4; BA325O24.3; FLJ40584; TSEPA; Thymocyte Expressed Molecule Involved In Selection; Signaling Phosphoprotein Specific For T Cells; Chromosome 6 Open Reading Frame 207; Chromosome 6 Open Reading Frame 190; GRB2-Associated Protein; GASP; SPOT |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified. |
| Buffer | PBS, 0.05% NaN3, 50% Glycerol and 0.1 % BSA. |
| Stabilizer | 50% Glycerol and 0.1 % BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | THEMIS |
| Gene Full Name | Thymocyte Selection Associated |
| Background | This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] |
| Function | Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. [Uniprot] |
| Cellular Localization | Cytoplasm, Nucleus. [Uniprot] |
| Calculated MW | 74 kDa |
| PTM | Phosphoprotein. [Uniprot] |
