ARG52445
anti-Thyroid Hormone Receptor alpha antibody [2103]
anti-Thyroid Hormone Receptor alpha antibody [2103] for Western blot and Human,Rat
Gene Regulation antibody; Neuroscience antibody; Signaling Transduction antibody
Overview
Product Description | Mouse Monoclonal antibody [2103] recognizes Thyroid Hormone Receptor alpha |
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Tested Reactivity | Hu, Rat |
Predict Reactivity | Ms, Dog, NHuPrm |
Tested Application | WB |
Host | Mouse |
Clonality | Monoclonal |
Clone | 2103 |
Isotype | IgG1 |
Target Name | Thyroid Hormone Receptor alpha |
Antigen Species | Human |
Immunogen | Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH |
Conjugation | Un-conjugated |
Alternate Names | c-ERBA-1; c-erbA-1; Thyroid hormone receptor alpha; V-erbA-related protein 7; AR7; NR1A1; Nuclear receptor subfamily 1 group A member 1; ERBA1; CHNG6; THRA1; THRA2; ERB-T-1; c-erbA-alpha; ERBA; EAR7; EAR-7 |
Application Instructions
Application Suggestion |
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Application Note | Specific for the ~50k TR-α1 and the ~58k TR-α2 proteins. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Protein G purified |
Buffer | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
Stabilizer | 0.1 mg/ml BSA, 50% Glycerol |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | THRA |
Gene Full Name | thyroid hormone receptor, alpha |
Background | Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005). |
Research Area | Gene Regulation antibody; Neuroscience antibody; Signaling Transduction antibody |
Calculated MW | 55 kDa |