ARG52448
anti-Thyroid Hormone Receptor beta antibody [2386]
anti-Thyroid Hormone Receptor beta antibody [2386] for Western blot and Human
Gene Regulation antibody; Neuroscience antibody; Signaling Transduction antibody
Overview
| Product Description | Mouse Monoclonal antibody [2386] recognizes Thyroid Hormone Receptor beta |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 2386 |
| Isotype | IgG1 |
| Target Name | Thyroid Hormone Receptor beta |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH |
| Conjugation | Un-conjugated |
| Alternate Names | C-ERBA-2; NR1A2; THRB1; ERBA2; Nuclear receptor subfamily 1 group A member 2; GRTH; C-ERBA-BETA; c-erbA-2; Thyroid hormone receptor beta; PRTH; THRB2; c-erbA-beta; THR1 |
Application Instructions
| Application Suggestion |
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| Application Note | Specific for the ~55k TR-β protein. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein G purified |
| Buffer | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| Stabilizer | 0.1 mg/ml BSA, 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | THRB |
| Gene Full Name | thyroid hormone receptor, beta |
| Background | Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005). |
| Research Area | Gene Regulation antibody; Neuroscience antibody; Signaling Transduction antibody |
| Calculated MW | 53 kDa |
Clone References
CXCR4 regulates interneuron migration in the developing neocortex.
IHC / Mouse
