ARG40506

anti-TrkC antibody

anti-TrkC antibody for IHC-Formalin-fixed paraffin-embedded sections and Human,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes TrkC
Tested Reactivity Hu, Rat
Predict Reactivity Ms, Hm
Tested Application IHC-P
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name TrkC
Antigen Species Human
Immunogen Synthetic peptide corresponding to aa. 167-182 of Human TrkC. (DIRWMQLWQEQGEAKL)
Conjugation Un-conjugated
Alternate Names TRKC; Neurotrophic tyrosine kinase receptor type 3; Trk-C; TrkC tyrosine kinase; NT-3 growth factor receptor; GP145-TrkC; EC 2.7.10.1; gp145(trkC)

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P0.5 - 1 µg/ml
Application Note IHC-P: Antigen Retrieval: By heat mediation.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer 0.2% Na2HPO4, 0.9% NaCl, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA.
Preservative 0.05% Thimerosal and 0.05% Sodium azide
Stabilizer 5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 29613 Rat NTRK3

GeneID: 4916 Human NTRK3

Swiss-port # Q03351 Rat NT-3 growth factor receptor

Swiss-port # Q16288 Human NT-3 growth factor receptor

Gene Symbol NTRK3
Gene Full Name neurotrophic tyrosine kinase, receptor, type 3
Background This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Function Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein. [UniProt]
Calculated MW 94 kDa
PTM Ligand-mediated auto-phosphorylation. [UniProt]