ARG56195
anti-UACA antibody [UACA/1222]
anti-UACA antibody [UACA/1222] for Western blot and Human,Mouse
Overview
| Product Description | Mouse Monoclonal antibody [UACA/1222] recognizes UACA |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | UACA/1222 |
| Isotype | IgG1, kappa |
| Target Name | UACA |
| Antigen Species | Human |
| Immunogen | Recombinant human UACA protein. |
| Conjugation | Un-conjugated |
| Alternate Names | Uveal autoantigen with coiled-coil domains and ankyrin repeats; NUCLING |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 0.1 mg/ml BSA |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8CGB3 Mouse Uveal autoantigen with coiled-coil domains and ankyrin repeats Swiss-port # Q9BZF9 Human Uveal autoantigen with coiled-coil domains and ankyrin repeats |
|---|---|
| Gene Symbol | UACA |
| Gene Full Name | uveal autoantigen with coiled-coil domains and ankyrin repeats |
| Function | Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity). [UniProt] |
| Cellular Localization | Nuclear membrane |
| Calculated MW | 163 kDa |
