ARG40117
anti-UBA6 antibody
anti-UBA6 antibody for Western blot and Human
Overview
Product Description | Rabbit Polyclonal antibody recognizes UBA6 |
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Tested Reactivity | Hu |
Predict Reactivity | Ms |
Tested Application | WB |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | UBA6 |
Antigen Species | Human |
Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 861-889 of Human UBA6. |
Conjugation | Un-conjugated |
Alternate Names | E1-L2; MOP-4; Ubiquitin-activating enzyme 6; Ubiquitin-like modifier-activating enzyme 6; Ubiquitin-activating enzyme E1-like protein 2; UBE1L2; Monocyte protein 4 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
Positive Control | K562 |
Properties
Form | Liquid |
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Purification | Purification with Protein A and immunogen peptide. |
Buffer | PBS and 0.09% (W/V) Sodium azide. |
Preservative | 0.09% (W/V) Sodium azide. |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links |
Swiss-port # A0AVT1 Human Ubiquitin-like modifier-activating enzyme 6 |
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Gene Symbol | UBA6 |
Gene Full Name | ubiquitin-like modifier activating enzyme 6 |
Background | Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008] |
Function | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. [UniProt] |
Calculated MW | 118 kDa |