ARG64871
anti-UNC5C antibody
anti-UNC5C antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
Developmental Biology antibody; Neuroscience antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes UNC5C |
|---|---|
| Tested Reactivity | Hu, Ms |
| Predict Reactivity | Dog |
| Tested Application | ICC/IF, IHC-P |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | UNC5C |
| Antigen Species | Human |
| Immunogen | NCTVSEEPTGID |
| Conjugation | Un-conjugated |
| Alternate Names | UNC5H3; Protein unc-5 homolog C; Protein unc-5 homolog 3; Netrin receptor UNC5C |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-P: Antigen Retrieval: In Citrate buffer. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by antigen affinity chromatography. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Background | This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008] |
| Research Area | Developmental Biology antibody; Neuroscience antibody |
| Calculated MW | 103 kDa |
| PTM | Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent. |
