ARG56937
anti-UNG antibody [k1C12]
anti-UNG antibody [k1C12] for ICC/IF,Western blot and Human
Overview
Product Description | Mouse Monoclonal antibody [k1C12] recognizes UNG |
---|---|
Tested Reactivity | Hu |
Tested Application | ICC/IF, WB |
Host | Mouse |
Clonality | Monoclonal |
Clone | k1C12 |
Isotype | IgG2b, kappa |
Target Name | UNG |
Antigen Species | Human |
Immunogen | Recombinant fragment around aa. 1-313 of Human UNG. |
Conjugation | Un-conjugated |
Alternate Names | Uracil-DNA glycosylase; HIGM4; HIGM5; UNG1; UNG2; UNG15; UDG; DGU; EC 3.2.2.27 |
Application Instructions
Application Suggestion |
|
||||||
---|---|---|---|---|---|---|---|
Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
---|---|
Purification | Purification with Protein G. |
Buffer | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
Preservative | 0.02% Sodium azide |
Stabilizer | 10% Glycerol |
Concentration | 1 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
---|---|
Gene Symbol | UNG |
Gene Full Name | uracil DNA glycosylase |
Background | This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010] |
Function | Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. [UniProt] |
Calculated MW | 35 kDa |
PTM | Isoform 1 is processed by cleavage of a transit peptide. |