ARG59553

anti-UNG2 antibody

anti-UNG2 antibody for Western blot,ICC/IF and Mouse

Overview

Product Description Rabbit Polyclonal antibody recognizes UNG2
Tested Reactivity Ms
Predict Reactivity Hu
Tested Application ICC/IF, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name UNG2
Antigen Species Human
Immunogen A 17 aa peptide within the first 50 aa. of Human UNG2.
Conjugation Un-conjugated
Alternate Names Uracil-DNA glycosylase; HIGM4; HIGM5; UNG1; UNG2; UNG15; UDG; DGU; EC 3.2.2.27

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF20 µg/ml
WB1 - 2 µg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control 3T3 Cell Lysate
Observed Size 33 kDa

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS and 0.02% Sodium azide
Preservative 0.02% Sodium azide
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 22256 Mouse UNG

Swiss-port # P97931 Mouse Uracil-DNA glycosylase

Gene Symbol UNG
Gene Full Name uracil DNA glycosylase
Background This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
Function Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. [UniProt]
Cellular Localization Isoform 1: Mitochondrion. Isoform 2: Nucleus. [UniProt]
Calculated MW 35 kDa
PTM Isoform 1 is processed by cleavage of a transit peptide. [UniProt]