ARG54994

anti-UQCRB antibody

anti-UQCRB antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human

Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes UQCRB
Tested Reactivity Hu
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name UQCRB
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide corresponding to aa. 19-47 (Center) of Human UQCRB.
Conjugation Un-conjugated
Alternate Names Complex III subunit VII; Complex III subunit 7; UQCR6; UQPC; QP-C; UQBP; Cytochrome b-c1 complex subunit 7; Ubiquinol-cytochrome c reductase complex 14 kDa protein; QCR7; QPC; MC3DN3; UQBC

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-PAssay-dependent
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control NCI-H292

Properties

Form Liquid
Purification Purification with Protein A and immunogen peptide.
Buffer PBS and 0.09% (W/V) Sodium azide
Preservative 0.09% (W/V) Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 7381 Human UQCRB

Swiss-port # P14927 Human Cytochrome b-c1 complex subunit 7

Gene Symbol UQCRB
Gene Full Name ubiquinol-cytochrome c reductase binding protein
Background This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]
Function This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping. [UniProt]
Cellular Localization Mitochondrion inner membrane.
Research Area Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody
Calculated MW 14 kDa