ARG45085
anti-VAV2 Phospho (Tyr172) antibody
anti-VAV2 Phospho (Tyr172) antibody for Western blot,ICC/IF and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes VAV2 Phospho (Tyr172) |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | VAV2 |
| Antigen Species | Mouse |
| Immunogen | Phospho-Vav2 (Tyr-172) synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding Tyr-172 in mouse Vav2. This sequence has high homology with similar regions in rat and human Vav2, and has significant homology to the conserved site in Vav1 and Vav3. |
| Conjugation | Un-conjugated |
| Alternate Names | VAV2; Vav Guanine Nucleotide Exchange Factor 2; Guanine Nucleotide Exchange Factor VAV2; Vav 2 Oncogene; VAV-2; Vav 2 Guanine Nucleotide Exchange Factor |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified. |
| Buffer | PBS, 0.05% NaN3, 50% Glycerol and 0.1 % BSA. |
| Stabilizer | 50% Glycerol and 0.1 % BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P52735 Human Guanine nucleotide exchange factor VAV2 Swiss-port # Q60992 Mouse Guanine nucleotide exchange factor VAV2 |
|---|---|
| Gene Symbol | VAV2 |
| Gene Full Name | Vav Guanine Nucleotide Exchange Factor 2 |
| Background | VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| Function | Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. [Uniprot] |
| Calculated MW | 101 kDa |
| PTM | Phosphoprotein. [Uniprot] |
