ARG56212

anti-VEGFC antibody

anti-VEGFC antibody for Western blot and Human,Mouse,Rat

publication_link Publication1

Overview

Product Description Mouse Monoclonal antibody recognizes VEGFC
Tested Reactivity Hu, Ms, Rat
Tested Application WB
Host Mouse
Clonality Monoclonal
Clone 197CT7.3.4
Isotype IgG1, kappa
Target Name VEGFC
Antigen Species Human
Immunogen Human VEGFC recombinant protein.
Conjugation Un-conjugated
Alternate Names VRP; Flt4-L; VEGF-C; Vascular endothelial growth factor-related protein; Flt4 ligand; Vascular endothelial growth factor C; LMPH1D

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control 293

Properties

Form Liquid
Purification Purification with Protein G.
Buffer PBS and 0.09% (W/V) Sodium azide.
Preservative 0.09% (W/V) Sodium azide.
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 114111 Rat VEGFC

GeneID: 22341 Mouse VEGFC

GeneID: 7424 Human VEGFC

Gene Symbol VEGFC
Gene Full Name vascular endothelial growth factor C
Background The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]
Function Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. [UniProt]
Cellular Localization Secreted.
Calculated MW 47 kDa
PTM Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.

Specific References

Characteristic Features of Deep Brain Lymphatic Vessels and Their Regulation by Chronic Stress

WB/IP / Mouse

JUNZHUANG CHANG et al.
RESEARCH ARTICLE,  (2023)

publication_link

 

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