ARG55018

anti-WIBG antibody

anti-WIBG antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human

Gene Regulation antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes WIBG
Tested Reactivity Hu
Predict Reactivity Ms, Bov
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name WIBG
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide corresponding to aa. 12-40 (N-terminus) of Human WIBG.
Conjugation Un-conjugated
Alternate Names WIBG; Partner of Y14 and mago; PYM; Protein wibg homolog

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-PAssay-dependent
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control U-251MG

Properties

Form Liquid
Purification Purification with Protein A and immunogen peptide.
Buffer PBS and 0.09% (W/V) Sodium azide
Preservative 0.09% (W/V) Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 84305 Human PYM1

Swiss-port # Q9BRP8 Human Partner of Y14 and mago

Gene Symbol WIBG
Gene Full Name within bgcn homolog (Drosophila)
Function Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. [UniProt]
Cellular Localization Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Shuttles between the nucleus and the cytoplasm Nuclear export is mediated by XPO1/CRM1
Research Area Gene Regulation antibody
Calculated MW 23 kDa