ARG44769
anti-WWP1 antibody
anti-WWP1 antibody for Immunoprecipitation and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes WWP1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IP |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Target Name | WWP1 |
| Antigen Species | Human |
| Conjugation | Un-conjugated |
| Alternate Names | NEDD4-like E3 ubiquitin-protein ligase WWP1; WW domain-containing protein 1; EC 6.3.2.-; Atrophin-1-interacting protein 5; Tiul1; hSDRP1; AIP5; TGIF-interacting ubiquitin ligase 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9H0M0 Human NEDD4-like E3 ubiquitin-protein ligase WWP1 |
|---|---|
| Gene Symbol | WWP1 |
| Gene Full Name | WW domain containing E3 ubiquitin protein ligase 1 |
| Background | WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008] |
| Function | Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. [UniProt] |
| Cellular Localization | Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. [UniProt] |
| Calculated MW | 105 kDa |
| PTM | Auto-ubiquitinated and ubiquitinated by RNF11. [UniProt] |
