ARG43803
anti-XCR1 / CCXCR1 antibody
anti-XCR1 / CCXCR1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes XCR1 / CCXCR1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | XCR1 / CCXCR1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein corresponding to a.a. F246-N274 of Human XCR1 / CCXCR1. |
| Conjugation | Un-conjugated |
| Protein Full Name | Chemokine XC receptor 1 |
| Alternate Names | XCR1; X-C Motif Chemokine Receptor 1; CCXCR1; GPR5; Chemokine (C Motif) XC Receptor 1; Chemokine (C Motif) Receptor 1; Chemokine XC Receptor 1; XC Chemokine Receptor 1; Lymphotactin Receptor; G Protein-Coupled Receptor 5; G-Protein Coupled Receptor 5 |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-P: Antigen Retrieval: Heat mediation was performed in EDTA buffer (pH 8.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| Positive Control | RT4; U-87MG; HEL; U2OS; Human spleen; Rat spleen tissue; Mouse spleen; Mouse thymus tissue; Rat thymus. | ||||||
| Observed Size | ~42 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | XCR1 |
| Gene Full Name | X-C Motif Chemokine Receptor 1 |
| Background | The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2020] |
| Function | Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin. [UniProt] |
| Cellular Localization | Cell membrane; Membrane. [UniProt] |
| Calculated MW | 38.5 kDa |
| PTM | Disulfide bond. [UniProt] |
