ARG44770
anti-XIAP antibody
anti-XIAP antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes XIAP |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, IP, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Target Name | XIAP |
| Antigen Species | Human |
| Conjugation | Un-conjugated |
| Alternate Names | XLP2; MIHA; hIAP3; Baculoviral IAP repeat-containing protein 4; EC 6.3.2.-; API3; hIAP-3; hILP; ILP1; BIRC4; E3 ubiquitin-protein ligase XIAP; IAP-like protein; IAP-3; Inhibitor of apoptosis protein 3; ILP; X-linked inhibitor of apoptosis protein; X-linked IAP |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | XIAP |
| Gene Full Name | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase |
| Background | BIRC-4 (for baculoviral IAP repeat-containing protein 4) is a member of the IAP (for Inhibitor of apoptosis protein) family proteins. Other Aliases include RP1-315G1.5, API3, ILP1, MIHA, XIAP, XLP2. BIRC4 inhibits activated caspase-3 and apoptosis. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. [UniProt] |
