ARG57763

anti-XPA antibody [71H3]

anti-XPA antibody [71H3] for Western blot and Human

Overview

Product Description Mouse Monoclonal antibody [71H3] recognizes XPA
Tested Reactivity Hu
Tested Application WB
Host Mouse
Clonality Monoclonal
Clone 71H3
Isotype IgG1, kappa
Target Name XPA
Antigen Species Human
Immunogen Recombinant protein around aa. 1-273 of Human XPA.
Conjugation Un-conjugated
Alternate Names XP1; XPAC; Xeroderma pigmentosum group A-complementing protein; DNA repair protein complementing XP-A cells

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein A.
Buffer PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 10% Glycerol
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 7507 Human XPA

Swiss-port # P23025 Human DNA repair protein complementing XP-A cells

Gene Symbol XPA
Gene Full Name xeroderma pigmentosum, complementation group A
Background This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Function Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. [UniProt]
Calculated MW 31 kDa
PTM ATR-dependent phosphorylation of XPA at Ser-196 is important for cell survival in response to UV damage.

Ubiquitinated by HERC2 leading to degradation by the proteasome. [UniProt]