ARG59617
anti-XPB antibody
anti-XPB antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes XPB |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | XPB |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 512-782 of Human XPB (NP_000113.1). |
| Conjugation | Un-conjugated |
| Alternate Names | TFIIH 89 kDa subunit; TFIIH basal transcription factor complex helicase XPB subunit; TTD2; RAD25; TFIIH p89; TFIIH basal transcription factor complex 89 kDa subunit; BTF2; Basic transcription factor 2 89 kDa subunit; XPB; BTF2 p89; DNA repair protein complementing XP-B cells; Xeroderma pigmentosum group B-complementing protein; EC 3.6.4.12; TFIIH; GTF2H; DNA excision repair protein ERCC-3 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Rat kidney, Mouse kidney and Jurkat | ||||
| Observed Size | 89 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ERCC3 |
| Gene Full Name | excision repair cross-complementation group 3 |
| Background | This gene encodes an ATP-dependent DNA helicase that functions in nucleotide excision repair. The encoded protein is a subunit of basal transcription factor 2 (TFIIH) and, therefore, also functions in class II transcription. Mutations in this gene are associated with Xeroderma pigmentosum B, Cockayne's syndrome, and trichothiodystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| Function | ATP-dependent 3'-5' DNA helicase, component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 89 kDa |
