ARG58746
anti-ZEB2 antibody
anti-ZEB2 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ZEB2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ZEB2 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1050-1214 of Human ZEB2 (NP_055610.1). |
| Conjugation | Un-conjugated |
| Alternate Names | Zinc finger E-box-binding homeobox 2; SIP-1; SIP1; SMADIP1; Smad-interacting protein 1; Zinc finger homeobox protein 1b; HSPC082; ZFHX1B |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O60315 Human Zinc finger E-box-binding homeobox 2 Swiss-port # Q9R0G7 Mouse Zinc finger E-box-binding homeobox 2 |
|---|---|
| Gene Symbol | ZEB2 |
| Gene Full Name | zinc finger E-box binding homeobox 2 |
| Background | The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010] |
| Function | Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 136 kDa |
| PTM | Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity. [UniProt] |
